Concern · Active

Lowering your homocysteine

Working on it together since April 2026

Active

A known compound-heterozygous MTHFR variant reduces the body's ability to activate folate, which can push...

Rather than standard folic acid, the approach uses already-methylated B-vitamin forms that bypass the genetic bottleneck.

Next step

Recheck homocysteine on the current methylated-B regimen and confirm it is trending toward the optimal longevity target...

What we think is going on

One line of work is active.

01 / 01compound-heterozygous MTHFR genotypeWorking

compound-heterozygous MTHFR genotype is active.

A compound-heterozygous MTHFR genotype impairs folate methylation and predisposes to elevated homocysteine, an independent risk marker for cardiovascular and...

What we're watching
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What you're doing

Nothing separate from the story cards right now.

Next step

Recheck homocysteine on the current methylated-B regimen and confirm it is trending toward the optimal longevity target...