Concern · Active

Healing your muscles after alcohol

Working on it together since May 2025

Improving

Latest CK signal is in range.

Decade-plus pattern of alcohol-triggered cramping escalated to documented rhabdomyolysis-range CK (1927) in Jan 2024, prompting...

Next step

Complete SS-31 titration through Day 14 (May 8) cleanly with KPV pre-treatment, then collect Day 28 labs (~May 22) for first...

What we think is going on

2 connected lines of work are active.

01 / 02Acquired mitochondrial cardiolipinWorking

Acquired mitochondrial cardiolipin is active.

Acquired mitochondrial cardiolipin damage from cumulative alcohol exposure, pool of damaged-but-recoverable mitochondria, primarily skeletal muscle, that responds to...

What you're doing

Sobriety since 2025-05, removes the dominant insult enabling repair

SS-31 titration 5 10 15mg (Apr 25, May 8), then 15mg daily through May 29, cardiolipin...

MOTS-C 5mg 2×/wk (May 9, Aug 22), biogenesis via AMPK PGC-1α

KPV pre-treat (500mcg ~90 min pre-injection) for ISR mitigation

02 / 02Underlying neuromuscular reactivityWorking

Underlying neuromuscular reactivity is active.

Underlying neuromuscular reactivity substrate, presumed channelopathy or membrane-excitability defect at the calcium-handling / ion-channel level, with susceptibility...

What you're doing

Class-aware trigger avoidance: alcohol, PT-141, kava, schisandra, pentoxifylline /...

Magnesium glycinate (membrane excitability stabilization)

Daily fasciculation / cramping / recovery diary

Aldolase, never measured; add at Day 42 to separate ongoing myopathy from exercise-induced...

What you're doing

ADORA2A variant + CYP1A2 fast (caffeine/methylxanthine sensitivity)

fast COMT (cAMP-relevant clearance)

MTHFR compound het

ALPL hypomorph (chronic low ALP, pyridoxine-5'-phosphate bottleneck, can affect membrane excitability via GABA synthesis)

RYR1, CACNA1S, SCN4A, ATP2A1/SERCA1, CPT2, PYGM, LPIN1, ANO5, DYSF, not on StrateGene chip; require dedicated metabolic-myopathy NGS panel

Next step

Complete SS-31 titration through Day 14 (May 8) cleanly with KPV pre-treatment, then collect Day 28 labs (~May 22) for first...